Acid-Catalyzed Synthesis of Aryl[4,5]isothiazoles through a Sulfenic Acid Pathway
Hong Yuan, Zhihua Sun*
*College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620, P. R. of China,
Email: sungaris
gmail.com
H. Yuan, Z. Sun, Synlett, 2019, 30, 1904-1908.
DOI: 10.1055/s-0039-1690201 (free Supporting Information)
Abstract
An acid-catalyzed thermolysis of a tert-butyl sulfoxide enables a simple synthesis of 3-substituted aryl[4,5]isothiazoles. Substituted aryl rings of varying electronic properties afford aryl[4,5]isothiazoles in high yields in the presence of a catalytic amount of p-toluenesulfonic acid in toluene.
see article for more examples
Synthesis of 3-Substituted Aryl[4,5]isothiazoles through an All-Heteroatom Wittig-Equivalent Process
F. Xu, Y. Chen, E. Fan, Z. Sun, Org. Lett., 2016, 18, 2777-2779.
Key Words
benzisothiazoles, catalytic reactions, synthetic methods
ID: J72-Y2019
