Cu(OTf)₂-Catalyzed Beckmann Rearrangement of Ketones Using Hydroxylamine-O-sulfonic Acid (HOSA)

Sailu Munnuri, Saumya Verma, Dinesh Chandra, Raghunath Reddy Anugu, John R. Falck, Jawahar L. Jat*

*Department of Chemistry, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India, Email: jawaharljbbau.ac.in

S. Munnuri, S. Verma, D. Chandra, R. R. Anugu, J. R. Falck, J. L. Jat, Synthesis, 2019, 51, 3709-3714.

DOI: 10.1055/s-0039-1690005

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Abstract

The use of hydroxylamine-O-sulfonic acid (HOSA) as aminating reagent and Cu(OTf)₂ as catalyst enables a Beckmann rearrangement of ketones under mild reaction conditions. This method tolerates most functional groups and directly provides the desired amides in very good yields.

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Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media

S. Verma, P. Kumar, A. K. Khatana, D. Chandra, A. K. Yadav, B. Tiwari, J. L. Jat, Synthesis, 2020, 52, 1841-1846.

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Key Words

hydroxylamine-O-sulfonic acid (HOSA), ketones, Beckmann rearrangement, Cu(OTf)₂, amides

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ID: J66-Y2019