Cu(OTf)2-Catalyzed Beckmann Rearrangement of Ketones Using Hydroxylamine-O-sulfonic Acid (HOSA)
Sailu Munnuri, Saumya Verma, Dinesh Chandra, Raghunath Reddy Anugu, John R. Falck, Jawahar L. Jat*
*Department of Chemistry, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India, Email: jawaharljbbau.ac.in
S. Munnuri, S. Verma, D. Chandra, R. R. Anugu, J. R. Falck, J. L. Jat, Synthesis, 2019, 51, 3709-3714.
DOI: 10.1055/s-0039-1690005 (free Supporting Information)
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The use of hydroxylamine-O-sulfonic acid (HOSA) as aminating reagent and Cu(OTf)2 as catalyst enables a Beckmann rearrangement of ketones under mild reaction conditions. This method tolerates most functional groups and directly provides the desired amides in very good yields.
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