Formamides as Isocyanate Surrogates: A Mechanistically Driven Approach to the Development of Atom-Efficient, Selective Catalytic Syntheses of Ureas, Carbamates, and Heterocycles
Jeffrey Bruffaerts, Niklas von Wolff, Yael Diskin-Posner, Yehoshoa Ben-David and David Milstein*
*Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel,
Email: david.milstein
weizmann.ac.il
J. Bruffaerts, N. von Wolff, Y. Diskin-Posner, Y. Ben-David, D. Milstein, J. Am. Chem. Soc., 2019, 141, 16486-16493.
DOI: 10.1021/jacs.9b08942
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Abstract
A ruthenium-based pincer complex catalyzed acceptorless dehydrogenative coupling reactions of readily available formamide precursors for a selective access to a broad range of ureas, carbamates, and heterocycles. This highly atom-efficient approach avoids the use of hazardous isocyanates.
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Key Words
ID: J48-Y2019
