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Nonbifunctional Outer-Sphere Strategy Achieved Highly Active α-Alkylation of Ketones with Alcohols by N-Heterocyclic Carbene Manganese (NHC-Mn)

Xiao-Bing Lan, Zongren Ye, Ming Huang, Jiahao Liu, Yan Liu* and Zhuofeng Ke*

*Guangdong University of Technology, Guangzhou 510006; Sun Yat-sen University, Guangzhou 510275, People’s Republic of China, Email:,

X.-B. Lan, Z. Ye, M. Huang, J. Liu, Y. Liu, Z. Ke, Org. Lett., 2019, 21, 8065-8070.

DOI: 10.1021/acs.orglett.9b03030

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An easily accessible N-heterocyclic carbene manganese (NHC-Mn) system catalyzes highly active α-alkylation of ketones with alcohols. This system was efficient for a wide range of ketones and alcohols under mild reaction conditions, and also for the green synthesis of quinoline derivatives.

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Key Words

α-alkylation of ketones

ID: J54-Y2019