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Synthesis of Asymmetrical 2,6-Diarylpyridines from Linear α,β,γ,δ-Unsaturated Ketones by Addition of Ammonium Formate Followed by Annulation

Yejun Gao, Rener Chen*, Yongmin Ma*

*School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P. R. China, Email: cretzc.edu.cn, yongmin.matzc.edu.cn

Y. Gao, R. Chen, Y. Ma, Synthesis, 2019, 51, 3875-3882.

DOI: 10.1055/s-0037-1610725 (free Supporting Information)


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Abstract

An efficent cyclization of readily available α,β,γ,δ-unsaturated ketones with ammonium formate under air atmosphere provides asymmetrical 2,6-diarylpyridines. The reaction is metal-free and operationally convenient.

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Key Words

regioselectivity, Michael addition, annulations, 2,4-dien-1-one, asymmetrical pyridines, oxygen


ID: J66-Y2019