Reductive Halogenation Reactions: Selective Synthesis of Unsymmetrical α-Haloketones
Zhiqi Lao, Huimiao Zhang and Patrick H. Toy*
*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. of China,
Email: phtoy
hku.hk
Z. Lao, H. Zhang, P. H. Toy, Org. Lett., 2019, 21, 8149-8152.
DOI: 10.1021/acs.orglett.9b02324
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Abstract
A triphenylphosphine oxide catalyzed reductive halogenation of an α,β-unsaturated ketone with trichlorosilane as the reducing reagent and an N-halosuccinimide as the electrophilic halogen source enables a selective synthesis of unsymmetrical α-haloketones.
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Key Words
Wittig reaction, enones, bromination, trichlorosilane, NBS
ID: J54-Y2019
