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Direct C-H Methylsulfonylation of Alkenes with the Insertion of Sulfur Dioxide

Fu-Sheng He, Xinxing Gong, Pornchai Rojsitthisak and Jie Wu*

*School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China, Email:

F.-S. He, Y. Gong, P. Rojsitthisak, J. Wu, J. Org. Chem., 2019, 84, 13159-13163.

DOI: 10.1021/acs.joc.9b01729

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The use of inorganic sodium metabisulfite as the sulfur dioxide surrogate and di-tert-butyl peroxide as source of the methyl radical enables a direct C-H methylsulfonylation of alkenes. This method provides convenient access to (E)-2-methyl styrenyl sulfones in good yields.

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Key Words

vinylation, alkylation, multicomponent reactions, DTBP

ID: J42-Y2019