Fe-Catalyzed Reductive Couplings of Terminal (Hetero)Aryl Alkenes and Alkyl Halides under Aqueous Micellar Conditions
Haobo Pang, Ye Wang, Fabrice Gallou and Bruce H. Lipshutz*
*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu
H. Pang, Y. Wang, F. Gallou, B. H. Lipshutz, J. Am. Chem. Soc., 2019, 141, 17117-17124.
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A reductive coupling of a vinyl-substituted aromatic or heteroaromatic and an alkyl bromide or iodide occurs in an aqueous micellar medium in the presence of Zn and a catalytic amount of an Fe(II) salt at rt. The new C-C bond is regiospecifically formed at rt at the β-site of the alkene via a radical process.
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