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A Convenient Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Arylamidines via Chloramine-T Mediated Intramolecular Oxidative N-N Bond Formation

Ashish Bhatt*, Rajesh K. Singh, Ravi Kant, Bhupendra K. Sarma

*Department of Chemistry, Mewar University, Chittorgarh, Rajasthan-312901, India, Email:

A. S. Singh, A. K. Agrahari, S. K. Singh, M. S. Yadav, V. K. Tiwari, Synthesis, 2019, 51, 3443-3450.

DOI: 10.1055/s-0037-1611906

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A convenient synthesis of 1,5-fused 1,2,4-triazoles in high yields from readily available N-arylamidines is efficiently promoted by chloramine-T through direct metal-free oxidative N-N bond formation. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol.

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Key Words

N-arylamidines, [1,2,4]triazolo[1,5-a]pyridines, [1,2,4]triazolo[1,5-a]pyrazines, [1,2,4]triazolo[1,5-a]pyrimidines, chloramine-T, ethanol

ID: J66-Y2019