Chemoselective Luche-Type Reduction of α,β-Unsaturated Ketones by Magnesium Catalysis

Yoon Kyung Jang, Marc Magre* and Magnus Rueping*

*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany, Email: marc.magreoc.rwth-aachen.de, magnus.ruepingrwth-aachen.de

Y. K. Jang, M. Magre, M. Rueping, Org. Lett., 2019, 21, 8349-8352.

DOI: 10.1021/acs.orglett.9b03131

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Abstract

A readily available Mg catalyst enables a chemoselective reduction of a wide range of α,β-unsaturated ketones in excellent yields under mild reaction conditions, short times, and low catalyst loadings.

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proposed mechanism

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Key Words

Luche-Type Reduction, Pinacolborane, 1,2-Reduction of Enones

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ID: J54-Y2019