Construction of Esters through Sulfuryl Fluoride (SO2F2) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature
Shi-Meng Wang, Njud S. Alharbi, Hua-Li Qin*
*School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, P. R. of China, Email: qinhualiwhut.edu.cn
S.-M. Wang, N. S. Alharbi, H.-L. Qin, Synthesis, 2019, 51, 3901-3907.
DOI: 10.1055/s-0039-1690017 (free Supporting Information)
Sulfuryl fluoride (SO2F2) mediates a dehydrative coupling of carboxylic acids with alcohols at room temperature and proceed with high efficiency. This method offers broad substrate scope, mild conditions, excellent functional group compatibility and affords esters in high yields, even on gram scale.
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esters, sulfuryl fluoride, dehydrative coupling, carboxylic acids, alcohols