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Construction of Esters through Sulfuryl Fluoride (SO2F2) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature

Shi-Meng Wang, Njud S. Alharbi, Hua-Li Qin*

*School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, P. R. of China, Email:

S.-M. Wang, N. S. Alharbi, H.-L. Qin, Synthesis, 2019, 51, 3901-3907.

DOI: 10.1055/s-0039-1690017


Sulfuryl fluoride (SO2F2) mediates a dehydrative coupling of carboxylic acids with alcohols at room temperature with high efficiency. This method offers broad substrate scope, mild conditions, excellent functional group compatibility and affords esters in high yields, even on gram scale.

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Key Words

esters, sulfuryl fluoride, dehydrative coupling, carboxylic acids, alcohols

ID: J66-Y2019