Palladium-Catalyzed Carboxylate-Assisted Ethoxycarboxylation of Aromatic Acids To Synthesize Monoethyl Phthalate Derivatives with Ethyl Bromodifluoroacetate
Na Tao, Jie Wang, Chunchen Yuan, Runsheng Zeng*, and Ying-Sheng Zhao*
*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China, Email: yszhaosuda.edu.cn, zengrunshengsuda.edu.cn
N. Tao, J. Wang, C. Yuan, R. Zeng, Y.-S. Zhao, Org. Lett., 2019, 21, 8607-8610.
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Ethyl bromodifluoroacetate as carbonyl source enables an efficient direct carbonation of aromatic acids to yield monoalkyl phthalate derivatives in good yields. A broad range of substrates bearing various functional groups were tolerated.
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carboxylation, copper salts, oxygen