Photoredox-Catalyzed Generation of Sulfamyl Radicals: Sulfonamidation of Enol Silyl Ether with Chlorosulfonamide
Qiyu Luo, Runyu Mao, Yan Zhu and Yonghui Wang*
*Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong, Shanghai 201203, China, Email: yonghuiwangfudan.edu.cn
Q. Luo, R. Mao, Y. Zhu, Y. Wang, J. Org. Chem., 2019, 84, 13897-13907.
DOI: 10.1021/acs.joc.9b02062
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Abstract
A practical photoredox-catalyzed generation of sulfamyl radicals followed by radical sulfonamidation of enol silyl ether provides functionalized β-ketosulfonamides in good yields under mild conditions.
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proposed mechanism
Key Words
sulfonamides, photochemistry
ID: J42-Y2019