Organic Chemistry Portal



Free Radical Addition of Nitrile, Ketone, and Ester to Alkyne and the Selectivity Discussion

Yingxia Xiao and Zhong-Quan Liu*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China, Email:

Y. Xiao, Z.-Q. Liu, Org. Lett., 2019, 21, 8810-8813.

DOI: 10.1021/acs.orglett.9b03444 (free Supporting Information)

see article for more reactions


A convenient and general atom transfer radical addition (ATRA) of simple nitriles, ketones, and esters to alkynes provides a wide range of β,γ-unsaturated nitriles, ketones, and esters.

see article for more examples

Key Words

Nitriles, Carbonyl Compounds, tert-Butyl peroxybenzoate

ID: J54-Y2019