Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile

Hiroaki Tsuji*, Keisuke Hashimoto and Motoi Kawatsura*

*Department of Chemistry, College of Humanities & Sciences, Nihon University, Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan, Email: tsujichs.nihon-u.ac.jp, kawatsurchs.nihon-u.ac.jp

H. Tsuji, K. Hashimoto, M. Kawatsura, Org. Lett., 2019, 21, 8837-8841.

DOI: 10.1021/acs.orglett.9b03475

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Abstract

A nickel-catalyzed benzylic substitution of pimary and secondary benzyl 2,3,4,5,6-pentafluorobenzoates with a wide variety of malonate derivatives provides the corresponding alkylation products in good yields.

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Key Words

benzylation

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ID: J54-Y2019