Cu-Catalyzed Denitrogenative Transannulation of 3-Aminoindazoles To Assemble 1-Aminoisoquinolines and 3-Aminobenzothiophenes
Yao Zhou, Ya Wang, Yixian Lou and Qiuling Song*
*Institute of Next Generation Matter Transformation, College of Materials Science & Engineering at Huaqiao University, 668 Jimei Boulevard, Xiamen, Fujian 361021, China,
Email: qsong
hqu.edu.cn
Y. Zhou, Y. Wang, Y. Lou, Q. Song, Org. Lett., 2019, 21, 8869-8873.
DOI: 10.1021/acs.orglett.9b02288
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Abstract
A Cu-catalyzed denitrogenative transannulation of 3-aminoindazoles provides diverse functionalized 3-aminobenzothiophenes and 1-aminoisoquinolines. This transformation proceeds via an "extrude-and-sew" strategy with an unprecedented radical reactivity of 3-aminoindazoles.
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proposed mechanism
synthesis of aminobenzothiophenes (see article for more examples)
Key Words
ID: J54-Y2019
