A Bulky Three-Hindered Quadrant Bisphosphine Ligand: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes
Yuuki Sawatsugawa, Ken Tamura, Natsuhiro Sano and Tsuneo Imamoto*
*Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan,
Email: imamoto
faculty.chiba-u.jp
Y. Sawatsugawa, K. Tamura, N. Sano, T. Imamoto, Org. Lett., 2019, 21, 8874-8878.
DOI: 10.1021/acs.orglett.9b02702
see article for more reactions
Abstract
The bulky ligand di-1-adamantylphosphino(tert-butylmethylphosphino)methane is a crystalline solid and can be readily handled in air. Its rhodium(I) complex exhibits very high enantioselectivities and catalytic activities in the asymmetric hydrogenation of functionalized alkenes.
see article for more examples
Key Words
reduction of alkenes, reduction of α,β-unsatured compounds, hydrogen
ID: J54-Y2019
