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A Bulky Three-Hindered Quadrant Bisphosphine Ligand: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

Yuuki Sawatsugawa, Ken Tamura, Natsuhiro Sano and Tsuneo Imamoto*

*Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email: imamotofaculty.chiba-u.jp

Y. Sawatsugawa, K. Tamura, N. Sano, T. Imamoto, Org. Lett., 2019, 21, 8874-8878.

DOI: 10.1021/acs.orglett.9b02702 (free Supporting Information)



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Abstract

The bulky ligand di-1-adamantylphosphino(tert-butylmethylphosphino)methane is a crystalline solid and can be readily handled in air. Its rhodium(I) complex exhibits very high enantioselectivities and catalytic activities in the asymmetric hydrogenation of functionalized alkenes.

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Key Words

reduction of alkenes, reduction of α,β-unsatured compounds, hydrogen


ID: J54-Y2019