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Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters

Jianzhong Chen, Feilong Li, Fang Wang, Yawen Hu, Zhenfeng Zhang, Min Zhao* and Wanbin Zhang*

*Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240; East China University of Science and Technology, Shanghai 200237, P.R. China, Email: zhaomin6502sina.com, wanbinsjtu.edu.cn

J. Chen, F. Li, F. Wang, Y. Hu, Z. Zhang, M. Zhao, W. Zhang, Org. Lett., 2019, 21, 9060-9065.

DOI: 10.1021/acs.orglett.9b03452 (free Supporting Information)


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Abstract

An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters at 1 atm hydrogen pressure and room temperature provides chiral α-arylglycine fragments, which are widely found in many chiral products and bioactive molecules.

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Key Words

reduction of imines, hydrogen


ID: J54-Y2019