Sodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines
Wubing Yao*, Lili He, Deman Han and Aiguo Zhong
*School of Pharmaceutical and Materials Engineering, Taizhou University, Jiaojiang 318000, Zhejiang, China,
Email: icyyw2010
yeah.net
W. Yao, L. He, D. Han, A. Zhong, J. Org. Chem., 2019, 84, 14627-14635.
DOI: 10.1021/acs.joc.9b02211
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Abstract
Transition-metal-free catalytic protocols for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents enable the selective reduction of unactivated C-O bonds in amides. By altering the hydrosilane and solvent, the C-N bonds selectively breaks via a deacylative cleavage.
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Key Words
reduction of amides, acetamides, deacylation, triethoxysilane, PMHS
ID: J42-Y2019
