Ni-Catalyzed Regioselective Hydroalkoxylation of Branched 1,3-Dienes
Gaël Tran and Clément Mazet*
*Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva, Switzerland, Email: clement.mazetunige.ch
G. Tran, C. Mazet, Org. Lett., 2019, 21, 9060-9065.
DOI: 10.1021/acs.orglett.9b03511 (free Supporting Information)
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The use of a (P,N) ligand enables a highly regioselective Ni-catalyzed hydroalkoxylation of 1,3-dienes. The optimized protocol operates under particularly mild conditions, provides access to a broad range of structurally diverse allylic ethers, and tolerates a number of sensitive functional groups.
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