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Tantalum-Catalyzed Amidation of Amino Acid Homologues

Wataru Muramatsu* and Hisashi Yamamoto*

*Molecular Catalyst Research Center, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan, Email: muramatsuisc.chubu.ac.jp, hyamamotoisc.chubu.ac.jp

W. Muramatshu, H. Yamamoto, J. Am. Chem. Soc., 2019, 141, 18926-18931.

DOI: 10.1021/jacs.9b08415 (free Supporting Information)


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Abstract

A mild, tantalum-catalyzed solvent-free approach for the construction of amide bonds in the presence of 1-(trimethylsilyl)imidazole provides peptides in high yields without any epimerization.

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Key Words

amides


ID: J48-Y2019