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Tantalum-Catalyzed Amidation of Amino Acid Homologues

Wataru Muramatsu* and Hisashi Yamamoto*

*Molecular Catalyst Research Center, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan, Email:,

W. Muramatshu, H. Yamamoto, J. Am. Chem. Soc., 2019, 141, 18926-18931.

DOI: 10.1021/jacs.9b08415

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A mild, tantalum-catalyzed solvent-free approach for the construction of amide bonds in the presence of 1-(trimethylsilyl)imidazole provides peptides in high yields without any epimerization.

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Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N- and C-Termini of Dipeptide

T. Hattori, H. Yamamoto, J. Am. Chem. Soc., 2022, 144, 1758-1765.

Peptide Bond Formation of Amino Acids by Transient Masking with Silylating Reagents

W. Muramatsu, H. Yamamoto, J. Am. Chem. Soc., 2021, 143, 6792-6797.

Key Words


ID: J48-Y2019