Tantalum-Catalyzed Amidation of Amino Acid Homologues
Wataru Muramatsu* and Hisashi Yamamoto*
*Molecular Catalyst Research Center, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan,
Email: muramatsu
isc.chubu.ac.jp, hyamamotoisc.chubu.ac.jp
W. Muramatshu, H. Yamamoto, J. Am. Chem. Soc., 2019, 141, 18926-18931.
DOI: 10.1021/jacs.9b08415
see article for more reactions
Abstract
A mild, tantalum-catalyzed solvent-free approach for the construction of amide bonds in the presence of 1-(trimethylsilyl)imidazole provides peptides in high yields without any epimerization.
see article for more examples
Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N- and C-Termini of Dipeptide
T. Hattori, H. Yamamoto, J. Am. Chem. Soc., 2022, 144, 1758-1765.
Peptide Bond Formation of Amino Acids by Transient Masking with Silylating Reagents
W. Muramatsu, H. Yamamoto, J. Am. Chem. Soc., 2021, 143, 6792-6797.
Key Words
ID: J48-Y2019
