Copper Aluminate Spinel in Click Chemistry: An Efficient Heterogeneous Nanocatalyst for the Highly Regioselective Synthesis of Triazoles in Water
Dariush Khalili*, Leila Kavoosi, Ali Khalafi-Nezhad
*Department of Chemistry, College of Sciences, Shiraz
University, Shiraz, 71454, Iran,
Email: khalili
shirazu.ac.ir
D. Khalili, L. Kavoosi, A. Khalafi-Nezhad, Synlett, 2019, 30, 2136-2142.
DOI: 10.1055/s-0039-1690719
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Abstract
Copper aluminate nanoparticles catalyze a multicomponent click reaction between organic azides (generated in situ from epoxides or halides) and terminal aliphatic or aromatic alkynes to provide 1,4-disubstituted (β-hydroxy)-1,2,3-triazoles in very good yields in an aqueous medium without the need for a reducing agent. The catalyst could be easily separated by simple filtration, recycled, and reused.
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Key Words
click chemistry, copper catalysis, triazoles, epoxides, azides, alkynes
ID: J72-Y2019
