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Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source

Jingjing Zhao, Pan Li*, Yaohua Xu, Yixin Shi and Fuwei Li*

*College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004; Lanzhou Institute of Chemical Physics, Lanzhou 730000, P. R. China, Email: panlihenu.edu.cn; fuweililicp.cas.cn

J. Zhao, P. Li, Y. Xu, Y. Shi, F. Li, Org. Lett., 2019, 21, 9386-9390.

DOI: 10.1021/acs.orglett.9b03610


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Abstract

A nickel-catalyzed reaction of acrylamides or enamides with diazoacetates provides indolin-2-ones or 1,4-dicarbonyl compounds in the presence of a peroxide and ethanol as hydrogen source and solvent.

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Key Words

oxindoles, TBPB


ID: J54-Y2019