Synthesis of N-Acyl Sulfamates from Fluorosulfonates and Potassium Trimethylsilyloxyl Imidates

Shuning Zhang, Huan Xiong, Fengping Lu, Fei Ma, Yuang Gu, Peixiang Ma*, Hongtao Xu* and Guang Yang*

*Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210 Shanghai, P. R. China, Email: mapxshanghaitech.edu.cn, xuhtshanghaitech.edu.cn, yangguangshanghaitech.edu.cn

S. Zhang, H. Xiong, F. Lu, F. Ma, Y. Gu, P. Ma, H. Xu, G. Yang, J. Org. Chem., 2019, 84, 15380-15388.

DOI: 10.1021/acs.joc.9b02394

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Abstract

An efficient and operationally simple synthesis of N-acyl sulfamates from fluorosulfonates and potassium trimethylsilyloxyl imidates as amide precursor offers broad substrate scope, mild and base-free reaction conditions, short reaction time, and excellent yields.

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Key Words

sulfamates

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ID: J42-Y2019