Direct Access to Allenylphosphine Oxides via a Metal Free Coupling of Propargylic Substrates with P(O)H Compounds
Chun-Hua Yang, Huihui Fan, Huimin Li, Shenyin Hou, Xiangkun Sun, Donghao Luo, Yinchao Zhang, Zhantao Yang* and Junbiao Chang*
*School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China,
Email: zhantaoyang163.com, changjunbiao
zzu.edu.cn
C.-H. Yang, H. Fan, H. Li, S. Hou, X. Sun, D. Luo, Y. Zhang, Z. Yang, J. Chang, Org. Lett., 2019, 21, 9438-9441.
DOI: 10.1021/acs.orglett.9b03645
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Abstract
A direct and convenient coupling of propargylic substrates with diphenylphosphine oxide in the presence of Tf2O and 2,6-lutidine provides attractive allenylphosphoryl skeletons with high atom and step economy under metal free conditions.
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proposed mechanism
Key Words
ID: J54-Y2019