Organic Chemistry Portal



Oxalic Acid Monothioester for Palladium-Catalyzed Decarboxylative Thiocarbonylation and Hydrothiocarbonylation

Bin Zhao, Yao Fu and Rui Shang*

*Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:

B. Zhao, Y. Fu, R. Shang, Org. Lett., 2019, 21, 9521-9526.

DOI: 10.1021/acs.orglett.9b03701

see article for more reactions


Oxalic acid monothioesters (OAM) can be used as a thioester synthetic equivalent for palladium-catalyzed decarboxylative thiocarbonylation of organohalides and hydrothiocarbonylation of unsaturated carbon-carbon bonds at room temperature with high chemo- and regioselectivity.

see article for more examples

Key Words

carboxylations, thioesters

ID: J54-Y2019