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Ligand-Controlled Regiodivergent Silylation of Allylic Alcohols by Ni/Cu Catalysis for the Synthesis of Functionalized Allylsilanes

Yi Gan, Wei Xu and Yuanhong Liu

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China, Email:

Y. Gan, W. Xu, Y. Liu, Org. Lett., 2019, 21, 9652-9657.

DOI: 10.1021/acs.orglett.9b03822

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Modulating the steric and electronic properties of the ligands on a nickel catalyst enables a Ni/Cu-catalyzed regiodivergent synthesis of allylsilanes directly from allylic alcohols. Good yields and excellent selectivity were obtained with linear and α-branched allylic alcohols as substrates.

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ID: J54-Y2019