Asymmetric Synthesis of Chiral Sulfoximines via the S-Arylation of Sulfinamides
Yusuke Aota, Taichi Kano* and Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan,
Email: kano
kuchem.kyoto-u.ac.jp, maruokakuchem.kyoto-u.ac.jp
Y. Aota, T. Kano, K. Maruoka, J. Am. Chem. Soc., 2019, 141, 19263-19268.
DOI: 10.1021/jacs.9b11298
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Abstract
A sulfur-selective arylation of easily accessible chiral sulfinamides enables an asymmetric synthesis of chiral sulfoximines. The utility of the present method is demonstrated by the asymmetric synthesis of a key intermediate of a COX-2 inhibitor.
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Practical Asymmetric Synthesis of Chiral Sulfoximines via Sulfur-Selective Alkylation
Y. Maeda, S. Hamada, Y. Aota, K. Otsubo, T. Kano, K. Maruoka, J. Org. Chem., 2022, 87, 3652-3660.
Key Words
ID: J48-Y2019
