LiHMDS-Promoted Palladium-Catalyzed Sonogashira Cross-Coupling of Aryl Fluorides with Terminal Alkynes
Jingjing He, Kang Yang, Jianhong Zhao* and Song Cao
*School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai 200237, China,
Email: zjhpharm
ecust.edu.cn
J. He, K. Yang, J. Zhao, S. Cao, Org. Lett., 2019, 21, 9714-9718.
DOI: 10.1021/acs.orglett.9b03815
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Abstract
A highly efficient Pd-catalyzed Sonogashira coupling of terminal alkynes with both unreactive electron-rich fluoroarenes and electron-poor fluoroarenes afforded the corresponding internal alkynes in good yields in the presence of LiHMDS.
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Key Words
ID: J54-Y2019
