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Recyclable Heterogeneous Copper(II)-Catalyzed Oxidative Cyclization of 2-Pyridine Ketone Hydrazones Towards [1,2,3]Triazolo[1,5-a]pyridines

Gan Jiang, Yang Lin, Mingzhong Cai*, Hong Zhao*

*Jiangxi Normal University, Nanchang 330022; Guangdong Pharmaceutical University, Guangzhou 510006, P. R. of China, Email:,

G. Jiang, Y. Lin, M. Cai, H. Zhao, Synthesis, 2019, 51, 4487-4497.

DOI: 10.1055/s-0037-1610726

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A heterogeneous copper(II)-catalyzed oxidative cyclization of 2-pyridine ketone hydrazones was achieved in ethyl acetate at room temperature in the presence of an MCM-41-anchored bidentate 2-aminoethylamino copper(II) catalyst and air as the oxidant to provide various [1,2,3]triazolo[1,5-a]pyridines in good yields. The catalyst can be recovered by filtration and reused at least seven times.

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Key Words

copper catalysis, [1,2,3]triazolo[1,5-a]pyridines, oxidative cyclization, oxygen, heterogeneous catalysis, N-N coupling

ID: J66-Y2019