Synthesis of Chiral Esters via Asymmetric Wolff Rearrangement Reaction
Jing Meng, Wei-Wei Ding and Zhi-Yong Han*
*Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China,
Email: hanzy2014
ustc.edu.cn
J. Meng, W.-W. Ding, Z.-Y. Han, Org. Lett., 2019, 21, 9801-9805.
DOI: 10.1021/acs.orglett.9b03227
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Abstract
An asymmetric Wolff rearrangement reaction directly converts α-diazoketones into broadly useful chiral α,α-disubstituted carboxylic esters with high enantioselectivities using visible-light-induced formation of the ketene intermediate and a readily available benzotetramisole-type catalyst for the asymmetric ketene esterification.
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Key Words
Wolff rearrangement, organocatalysis, photochemistry
ID: J54-Y2019
