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Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes

Dániel Lasányi and Gergely L. Tolnai*

*Institute of Chemistry, Eotvos Lorand University, Pazmany P. setany. 1/a, 1117 Budapest, Hungary, Email: tolnaichem.elte.hu

D. Lasányi, G. L. Tolnai, Org. Lett., 2019, 21, 10057-10062.

DOI: 10.1021/acs.orglett.9b03999 (free Supporting Information)


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Abstract

Propellanes have tremendous potential to be exploited in synthetic organic chemistry. An experimentally simple procedure provides cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with alkynes.

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Key Words

allenes, cyclobutanes


ID: J54-Y2019