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Selectfluor-Mediated Tandem Cyclization of Enaminones for the Synthesis of 3-Fluorochromones

Venu Kandula, Pradeep Kumar Thota, Poosa Mallesham, K. Raghavulu, Anindita Chatterjee, Satyanarayana Yennam, Manoranjan Behera*

*Chemistry Services, GVK Biosciences Pvt. Ltd., Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, Telangana, India, Email: manoranjan.beheragvkbio.com

V. Kandula, P. K. Thota, P. Mallesham, K. Raghavulu, A. Chatterjee, S. Yennam, M. Behera, Synlett, 2019, 30, 2295-2299.

DOI: 10.1055/s-0039-1691489 (free Supporting Information)


Abstract

An efficient cyclization of enamino ketones in the presence of Selectfluor provides various 3-fluorochromones (3-fluoro-4H-chromene-4-ones) in good yields. This method offers simple operational procedures, a high purity of the product, and excellent regioselectivity.

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Key Words

fluorochromones, chromones, enamino ketones, fluorination, Selectfluor


ID: J72-Y2019