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P-Chiral Phosphines Enabled by Palladium/Xiao-Phos-Catalyzed Asymmetric P-C Cross-Coupling of Secondary Phosphine Oxides and Aryl Bromides

Qiang Dai, Wenbo Li, Zhiming Li and Junliang Zhang*

*Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, China, Email: junliangzhangfudan.edu.cn

Q. Dai, W. Li, Z. Li, J. Zhang, J. Am. Chem. Soc., 2019, 141, 20556-20564.

DOI: 10.1021/jacs.9b11938 (free Supporting Information)


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Abstract

A Pd/Xiao-Phos-catalyzed cross-coupling reaction of easily accessible secondary phosphine oxides and aryl bromides provides rapid access to P-chiral phosphine oxides. The reaction proceeds efficiently with a wide array of reaction partners to deliver various tertiary phosphine oxides.

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Key Words

phosphine oxides


ID: J48-Y2019