Synergistic Copper-Catalyzed Reductive Aminocarbonylation of Alkyl Iodides with Nitroarenes
Siling Zhao and Neal P. Mankad*
*Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, United States, Email: npmuic.edu
S. Zhao, N. P. Mankad, Org. Lett., 2019, 21, 10106-10110.
DOI: 10.1021/acs.orglett.9b04092 (free Supporting Information)
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A Cu-catalyzed reductive aminocarbonylation of primary, secondary, and tertiary alkyl iodides using nitroarenes as the nitrogen source provides a diverse range of secondary N-aryl alkylamides. The single copper catalyst synergistically mediates both carbonylation of alkyl iodides and reduction of nitroarenes, to provide acyl iodides and anilines as possible reactive intermediates.
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