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Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines

Yuta Kondo, Tetsuya Kadota, Yoshinobu Hirazawa, Kazuhiro Morisaki, Hiroyuki Morimoto* and Takashi Ohshima*

*Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3-1-1 Higashi-ku, Fukuoka, Japan, 812-8582, Email: hmorimotphar.kyushu-u.ac.jp, ohshimaphar.kyushu-u.ac.jp

Y. Kondo, T. Kadota, Y. Hirazawa, K. Morisaki, H. Morimoto, T. Ohshima, Org. Lett., 2020, 22, 120-123.

DOI: 10.1021/acs.orglett.9b04038 (free Supporting Information)


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Abstract

Scandium(III) triflate catalyzes a direct synthesis of N-unprotected ketimines from ketones in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds without isolation of the N-unprotected ketimine intermediates.


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Key Words

Imines


ID: J54-Y2020