A Mild Synthesis of 2-Substituted Benzothiazoles via Nickel-Catalyzed Intramolecular Oxidative C-H Functionalization
Ming-Yuan Gao, Jing-Hang Li, Shi-Bo Zhang, Li-Jun Chen, Yue-Sheng Li* and Zhi-Bing Dong*
*School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China,
Email: frank78929
163.com, dzb04982wit.edu.cn
M.-Y. Gao, J.-H. Li, S.-B. Zhang, L.-J. Chen, Y.-S. Li, Z.-B. Dong, J. Org. Chem., 2020, 85, 493-500.
DOI: 10.1021/acs.joc.9b02543
Abstract
A nickel-catalyzed intramolecular oxidative C-H bond functionalization of arylthioureas provides 2-aminobenzothiazoles in very good yields and short reaction times. This protocol features an inexpensive catalyst, low catalyst loading, mild reaction conditions, and can be scaled up easily to a gram scale.
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ID: J42-Y2020
