Selective Methylation of Amides, N-Heterocycles, Thiols, and Alcohols with Tetramethylammonium Fluoride
Hong-Gang Cheng, Maoping Pu, Gourab Kundu and Franziska Schoenebeck*
*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany,
Email: franziska.schoenebeck
rwth-aachen.de
H.-G. Cheng, M. Pu, G. Kundu, F. Schoenebeck, Org. Lett., 2020, 22, 331-334.
DOI: 10.1021/acs.orglett.9b04400
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Abstract
Tetramethylammonium fluoride (TMAF) enables a direct and selective methylation of various amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification.
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Key Words
Amides, Indoles, N-alkylation of heterocycles
ID: J54-Y2020
