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The Development of Efficient Protocols for the Palladium-Catalyzed Cyclization Reactions of Secondary Amides and Carbamates

Bryant H. Yang and Stephen L. Buchwald

*Department of Chemistry, Massachusetts Institute of Technology, Room 18-490, Cambridge, Massachusetts 02139, Email:

B. H. Yang, S. L. Buchwald, Org. Lett., 1999, 1, 35-37.

DOI: 10.1021/ol9905351

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With the proper choice of palladium catalyst, ligand, and base, five-, six-, and seven-membered rings are formed efficiently from secondary amide or secondary carbamate precursors.

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Key Words

indolines, oxindoles, tetrahydroquinolines, dihydroquinolinones, benzo-fused N-heterocycles

ID: J54-Y1999