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New Efficient Nickel- and Palladium-Catalyzed Cross-Coupling Reactions Mediated by Tetrabutylammonium Iodide

Michael Piber, Anne Eeg Jensen, Mario Rottländer and Paul Knochel

*Institut für Organische Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377 München, Germany, Email:

M. Piber, A. E. Jensen, M. Rottländer, P. Knochel, Org. Lett., 1999, 1, 1323-1326.

DOI: 10.1021/ol9907872

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Bu4NI as additive accelerates the palladium(0)-catalyzed cross-coupling between benzylic zinc bromides and aryl or alkenyl triflates. Remarkably, it further enables a new nickel(0)-catalyzed cross-coupling between functionalized benzylic zinc reagents and primary alkyl iodides under mild reaction conditions.

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Key Words

benzylation, diarylmethanes, alkylation

ID: J54-Y1999