Synthesis of a Novel Chiral Binaphthyl Phospholane and Its Application in the Highly Enantioselective Hydrogenation of Enamides
Dengming Xiao, Zhaoguo Zhang and Xumu Zhang
*Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802,
Email: zhangxm
sustc.edu.cn
D. Xiao, Z. Zhang, X. Zhang, Org. Lett., 1999, 1, 1679-1681.
DOI: 10.1021/ol991074m
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Abstract
(R,R)-binaphane possesses both binaphthyl chirality and phospholane functionality. Excellent enantioselectivities have been observed in hydrogenation of an isomeric mixture of (E)- and (Z)-β-substituted-α-arylenamides by using a Rh-binaphane catalyst.
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W. Li, Z. Zhang, D. Xiao, X. Zhang, J. Org. Chem., 2000, 65, 3489-3496.
Key Words
Hydrogen, Reduction of Enamines
ID: J54-Y1999
