Organic Chemistry Portal



A Novel Synthesis of 2-Aryl-2H-indazoles via a Palladium-Catalyzed Intramolecular Amination Reaction

Jinhua J. Song and Nathan K. Yee

*Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368

J. J. Song, N. K. Yee, Org. Lett., 2000, 2, 519-521.

DOI: 10.1021/ol990409x

see article for more reactions


A palladium-catalyzed intramolecular amination enables the synthesis of various 2-aryl-2H-indazoles from N-aryl-N-(o-bromobenzyl)hydrazines. This reaction tolerates a wide range of electron-donating and electron-withdrawing substituents.

see article for more examples

Key Words


ID: J54-Y2000