Efficient Palladium-Catalyzed N-Arylation of Indoles

David W. Old, Michele C. Harris and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu

D. W. Old, M. C. Harris, S. L. Buchwald, Org. Lett., 2000, 2, 1403-1406.

DOI: 10.1021/ol005728z

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Abstract

Bulky, electron-rich phosphines as the supporting ligand in combination with Pd₂(dba)₃ enable N-arylation of indoles with aryl iodides, bromides, chlorides, and triflates.

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Key Words

Buchwald-Hartwig Coupling, Indoles, N-Arylation

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ID: J54-Y2000