High Turnover Number and Rapid, Room-Temperature Amination of Chloroarenes Using Saturated Carbene Ligands
Shaun R. Stauffer, Sunwoo Lee, James P. Stambuli, Sheila I. Hauck and John F. Hartwig
*Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, Email: jhartwigberkeley.edu
S. R. Stauffer, S. Lee, J. P. Stambuli, S. I. Hauck, J. F. Hartwig, Org. Lett., 2000, 2, 1423-1426.
see article for more reactions
A catalytic system consisting of a Pd(0) precursor and a dihydroimidazoline carbene ligand, which is generated in situ from its protonated tetrafluoroborate salt, enables a mild amination of aryl chlorides with secondary amines and anilines within hours at room temperature.
see article for more examples
Buchwald-Hartwig Coupling, arylamines