Pd(PhCN)₂Cl₂/P(t-Bu)₃:  A Versatile Catalyst for Sonogashira Reactions of Aryl Bromides at Room Temperature

Thomas Hundertmark, Adam F. Littke, Stephen L. Buchwald* and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu, gcfucaltech.edu

T. Hundertmark, A. F. Littke, S. L. Buchwald, G. C. Fu, Org. Lett., 2000, 2, 1729-1731.

DOI: 10.1021/ol0058947

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Abstract

Pd(PhCN)₂Cl₂/P(t-Bu)₃ serves as an efficient and a versatile catalyst for Sonogashira reactions of aryl bromides, accomplishing a wide range of couplings at room-temperature. This study provides further evidence of the usefulness of bulky, electron-rich phosphines in palladium-catalyzed coupling reactions.

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Key Words

Sonogashira coupling, alkynylation

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ID: J54-Y2000