Organic Chemistry Portal



Copper-Mediated Cross-Coupling of Aryl Boronic Acids and Alkyl Thiols

Prudencio S. Herradura, Kathleen A. Pendola and R. Kiplin Guy*

*University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0446, Email:

P. S. Herradura, K. A. Pendola, R. K. Guy, Org. Lett., 2000, 2, 2019-2022.

DOI: 10.1021/ol005832g

see article for more reactions


Copper(II) acetate and pyridine mediate a cross-coupling of aryl boronic acids and alkanethiols in anhydrous dimethylformamide to afford aryl alkyl sulfides in good yield.

see article for more examples

Key Words

Chan-Lam Coupling, Aryl Sulfides

ID: J54-Y2000