New Stable Reagents for the Nucleophilic Trifluoromethylation. 1. Trifluoromethylation of Carbonyl Compounds with N-Formylmorpholine Derivatives
T. Billard, S. Bruns and B. R. Langlois
*Synthèse, Electrosynthèse et Réactivité des Composés Organiques Fluorés (SERCOF), UMR CNRS 5622, Université Claude Bernard-Lyon I, 43 Bd du 11 Novembre 1918, F-69622 Villeurbanne, France
T. Billard, S. Bruns, B. R. Langlois, Org. Lett., 2000, 2, 2101-2103.
DOI: 10.1021/ol005987o
Abstract
The stable 4-[2,2,2-trifluoro-1-[(trimethylsilyl)oxy]ethyl]morpholine is a nucleophilic trifluoromethylating agent, that reacts with non nonenolizable carbonyl compounds to provide α-trifluoromethyl alcohols.
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Key Words
ID: J54-Y2000
