Expanded Scope in Ethylene-Alkyne Cross-Metathesis: Coordinating Heteroatom Functionality at the Propargylic Position
Jason A. Smulik and Steven T. Diver
*Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, Email: diverbuffalo.edu
J. A. Smulik, S. T. Diver, Org. Lett., 2000, 2, 2271-2274.
DOI: 10.1021/ol006035l (free Supporting Information)
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The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex also catalyzes ethylene-alkyne cross-metathesis of alkynes having free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered alkynes also react efficiently under the reported conditions.
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B. R. Galan, K. P. Kalbarczyk, S. Szczepankiewicz, J. B. Keister, S. T. Diver, Org. Lett., 2007, 9, 1203-1206.