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Expanded Scope in Ethylene-Alkyne Cross-Metathesis:  Coordinating Heteroatom Functionality at the Propargylic Position

Jason A. Smulik and Steven T. Diver

*Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, Email:

J. A. Smulik, S. T. Diver, Org. Lett., 2000, 2, 2271-2274.

DOI: 10.1021/ol006035l

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The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex also catalyzes ethylene-alkyne cross-metathesis of alkynes having free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered alkynes also react efficiently under the reported conditions.

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A Rapid and Simple Cleanup Procedure for Metathesis Reactions

B. R. Galan, K. P. Kalbarczyk, S. Szczepankiewicz, J. B. Keister, S. T. Diver, Org. Lett., 2007, 9, 1203-1206.

Key Words

enyne metathesis, 1,3-dienes

ID: J54-Y2000