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Dynamic Kinetic Resolution of Allylic Alcohols Mediated by Ruthenium- and Lipase-Based Catalysts

Donghyun Lee, Eun A. Huh, Mahn-Joo Kim*, Hyun Min Jung, Jeong Hwan Koh and Jaiwook Park*

*Department of Chemistry, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea, Email:,

D. Lee, E. A. Huh, M.-J. Kim, H. M. Jung, J. H. Koh, J. Park, Org. Lett., 2000, 2, 2377-2379.

DOI: 10.1021/ol006159y


A combination of a lipase and a ruthenium complex reaction enables a dynamic kinetic resolution of allylic alcohols in which racemic substrates react in the presence of an acyl donor to allylic acetates of high optical purity in very good yields.

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Highly Enantioselective Dynamic Kinetic Resolution of 1,2-Diarylethanols by a Lipase-Ruthenium Couple

M.-J. Kim, Y. K. Choi, S. Kim, D. Kim, K. Han, S.-B. Ko, J. Park, Org. Lett., 2008, 10, 1295-1298.

Key Words

Allylic Alcohols, Asymmetric Acylations

ID: J54-Y2000