Dynamic Kinetic Resolution of Allylic Alcohols Mediated by Ruthenium- and Lipase-Based Catalysts

Donghyun Lee, Eun A. Huh, Mahn-Joo Kim*, Hyun Min Jung, Jeong Hwan Koh and Jaiwook Park*

*Department of Chemistry, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea, Email: mjkimpostech.ac.kr, pjwpostech.ac.kr

D. Lee, E. A. Huh, M.-J. Kim, H. M. Jung, J. H. Koh, J. Park, Org. Lett., 2000, 2, 2377-2379.

DOI: 10.1021/ol006159y

---

Abstract

A combination of a lipase and a ruthenium complex reaction enables a dynamic kinetic resolution of allylic alcohols in which racemic substrates react in the presence of an acyl donor to allylic acetates of high optical purity in very good yields.

see article for more examples

---

---

Highly Enantioselective Dynamic Kinetic Resolution of 1,2-Diarylethanols by a Lipase-Ruthenium Couple

M.-J. Kim, Y. K. Choi, S. Kim, D. Kim, K. Han, S.-B. Ko, J. Park, Org. Lett., 2008, 10, 1295-1298.

---

Key Words

Allylic Alcohols, Asymmetric Acylations

---

ID: J54-Y2000