Asymmetric Transfer Hydrogenation of Benzaldehydes
Issaku Yamada and Ryoji Noyori*
*Department of Chemistry and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Email: noyorichem3.chem.nagoya-u.ac.jp
I. Yamada, R. Noyori, Org. Lett., 2000, 2, 3425-3427.
DOI: 10.1021/ol002119 (free Supporting Information)
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A combination of a chiral Ru complex and KOtBu catalyzes an asymmetric transfer hydrogenation of various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in high ee and with high isotopic purity. Reaction of benzaldehydes with a DCO2D-triethylamine mixture and the same Ru catalyst affords the S deuterated alcohols in high ee.
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